179897-89-3, name is 5-Bromo-2-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 179897-89-3
5-bromo-2-fluorobenzonitrile (1.0 g, 5.0 mmol) was weighed and dissolved in DMF (10 mL), Add K2CO3 (2.1 g, 15.0 mmol), stir at room temperature for 1.0 h, add N-methylisobutylamine (1.3 g, 15.0 mmol), and react at 80 C for 3 h. TLC followed the reaction completely.Cooled to room temperature, diluted with 100mL of water was added, ethyl acetate (100mL ¡Á 3). The combined organic phases were washed with brine, dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, purification by silica gel column (V ethyl acetate: V petroleum ether = 1: 20) afforded 5-bromo-2-isobutylmethylaminobenzonitrile (a10)1.27 g, yield 95%
Statistics shows that 179897-89-3 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2-fluorobenzonitrile.
Reference:
Patent; South China University of Technology; Li Jing; Li Xiaolei; Li Yuanyuan; Zhou Haiyan; Zhang Lei; Guan Su; (21 pag.)CN110078668; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts