Adding a certain compound to certain chemical reactions, such as: 23842-82-2, name is 2-Amino-5-methoxybenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23842-82-2, 23842-82-2
Ketone (¡À)-5 (95 mg, 0.63 mmol) was dissolved in dry 1,2-dichloroethane (1 mL). AnhydrousAlCl3 (126.5 mg, 0.95 mmol) and 7 (121 mg, 0.79 mmol) were added to this solution. The mixturewas stirred under MW (50W, 300 psi, high stirring) conditions at 95 C for 2 h. After the completionof the condensation, mixture of THF/H2O (7.5 mL, 2:1) was added, followed by 2 M aq. solution ofNaOH adjusting pH to 8-9. The resulting mixture was stirred for 30 min. The organic and aqueousphases were separated and the aqueous one was washed with dichloromethane (2 8 mL). Combinedorganic layers were dried over anhydrous Na2SO4 and the solvent was removed under reducedpressure. The crude product was purified by column chromatography (CH2Cl2/MeOH/TEA, 95:5:1).Compound (¡À)-1 (142 mg) was obtained in 80% yield in two steps as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Amino-5-methoxybenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mezeiova, Eva; Korabecny, Jan; Sepsova, Vendula; Hrabinova, Martina; Jost, Petr; Muckova, Lubica; Kucera, Tomas; Dolezal, Rafael; Misik, Jan; Spilovska, Katarina; Pham, Ngoc Lam; Pokrievkova, Lucia; Roh, Jaroslav; Jun, Daniel; Soukup, Ondrej; Kaping, Daniel; Kuca, Kamil; Molecules; vol. 22; 8; (2017);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts