These common heterocyclic compound, 332-25-2, name is 4-(Trifluoromethoxy)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 332-25-2
The 4 – trifluoro nitrile (187 mg, 1mmol), butyric aldehyde wo (96 mg, 1 . 1mmol), [Cp * IrCl2]2(8 mg, 0 . 01mmol, 1 muM percent), toluene (1 ml) are added to the 25 ml Schlenk reaction bottle. The mixture 100 ¡ãC reaction under 6 hours, cooling to room temperature. The benzyl alcohol (140 mg, 1 . 3mmol) and cesium carbonate (65 mg, 0.2 equiv.) is added to the bottle in the reaction, the mixture 130 ¡ãC then continue to react under 12 hours, cooling to room temperature. The solvent is removed by rotary evaporation, then through the column chromatography (developing solvent: ethyl acetate/petroleum ether) to obtain the pure target compound, yield: 82percent.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 332-25-2.
Reference:
Patent; Nanjing University of Science and Technology; Li Feng; Wang Nana; Zou Xiaoyuan; (15 pag.)CN105016938; (2017); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts