Introduction of a new synthetic route about 134227-45-5

The synthetic route of 3,4,5-Trifluorobenzonitrile has been constantly updated, and we look forward to future research findings.

A common heterocyclic compound, 134227-45-5, name is 3,4,5-Trifluorobenzonitrile, molecular formula is C7H2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 134227-45-5.

To N, N- dimethylformamide (10mL) solution of 3,4,5-trifluorobenzonitrile (305mg), phenol (213mg), cesium carbonate (760mg) were added,and the mixture was stirred for 3 h at 80 . Aftercooling the reaction mixture to room temperature, water was added, and themixture was extracted with ethyl acetate. The combined organic layerswere washed with saturated brine, dried over anhydrous magnesium sulfate, andconcentrated under reduced pressure. The resulting residue was purified bysilica gel column chromatography (eluent: ethyl acetate / heptane = 1/10), toobtain the desired product (387mg).

The synthetic route of 3,4,5-Trifluorobenzonitrile has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ISHIHARA SANGYO KAISHA LIMITED; TSUKUDA, SHINTARO; IWAMOTO, TAKUYA; MORIYAMA, TAICHI; (45 pag.)JP2016/56117; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts