170572-49-3, A common compound: 170572-49-3, name is 3-Fluoro-4-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Intermediate 54 2- [4- (5-cyano-2-methylphenoxy)-2-methylphenoxy]-2-methylpropionic acid ethyl ester Step A . 3-fluoro-4-methyl-5-nitrobenzonitrile; Add potassium nitrate (4.51 g, 44.54 mmol) in three or four portions to 3-fluoro-4- methylbenzonitrile (6.02 g, 44.54 mmol) in concentrated H2SO4 (50 ml) at 0C and stir. Stir the deep orange solution for 2 hours at 0C and then for 1 hour at rt. Add the mixture over 800 ml of ice and extract with 150 ml of AcOEt. Allow the mixture to warm at rt and separate the organic layer. Extract again the aqueous layer with 100 ml of AcOEt. Combine the organic extracts and washed with water (50 ml) and brine (50 ml). Dry the organic layer over magnesium sulfate, filter, and concentrate under reduced pressure to give the crude product (7.64 g, 93% yield). Although the product can be used without further purification, flash chromatogapy can be performed in silica using hexane: ethyl acetate (10: 1) as eluent.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/54176; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts