218632-01-0, name is 3-Fluoro-4-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 218632-01-0
3-Fluoro-4-nitrobenzonitrile (3.50 mmol, 581 mg) in CH2Cl2 (12 mL) was added Et3N (3.85 mmol, 0.54 mL) at -15 C. The reaction solution was stirred at -15 C. for 30 min. To the reaction solution was added 3-methoxypropan-1-amine (3.50 mmole, 0.36 mL) and stirred at -15 C. for 30 min. The cooling bath was removed to let the reaction solution warm to rt and kept stirring at rt for 30 min. The reaction solution containing 3-(3-methoxypropylamino)-4-nitrobenzonitrile (41A) was concentrated in vacuo and carried directly on to the next step without further purification. ESI-MS: m/z 236.3 (M+H)+.
Statistics shows that 218632-01-0 is playing an increasingly important role. we look forward to future research findings about 3-Fluoro-4-nitrobenzonitrile.
Reference:
Patent; Takeda Pharmaceutical Company Limited; US8138168; (2012); B1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts