78473-00-4, These common heterocyclic compound, 78473-00-4, name is 4-Amino-3,5-dichlorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(i) Preparation of N-trifluoroacetyl-4-cyano-2,6-dichloroaniline Twenty-five grams (0.1337 mole) of 4-cyano-2,6-dichloroaniline was dissolved in 250 ml of methylene chloride, and 30.9 g (20.8 ml, 0.1471 mole) of trifluoroacetic anhydride was added slowly with stirring. The solution was allowed to stand overnight and then was neutralized by the addition of 5% aqueous sodium carbonate, precipitating a white crystalline solid which was filtered and dried to give 28.0 g (74% yield) of N-trifluoroacetyl-4-cyano-2,6-dichloroaniline, m.p.: 134-136 C.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 78473-00-4.
Reference:
Patent; SmithKline Beckman Corporation; US4719223; (1988); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts