2973-50-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2973-50-4 name is 2-(2-Aminophenyl)acetonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a suitable amount of an organic solvent (a mixture of 1-cyanopropyl-3-methylimidazolium tetrafluoroborate and ethylene glycol at a mass ratio of 1: 4)The compound of formula (I) above 100mmo 1 is added,100mmo 1 The compound of formula (II)15 mmo 1 catalyst (3.75 mmol1-diphenylphosphino-1 ‘_ (di-tert-butylphosphino) ferrocene11.25 mmol Tin iodide mixture),150 mmol of base 1,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) with16 mmol Promoter Cerium triflate (Ce(OTf) 3), then warmed to 80 C, and the reaction was stirred at this temperature for 12 hours;[0036] After completion of the reaction, deionized water was added to the reaction system and thoroughly shaken, washed, and then extracted with chloroform 2-3 times,The combined organic phases were washed again with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was passed over 300-400 meshSilica gel column chromatography eluting with a mixture of acetone and petroleum ether in a volume ratio of 1: 2 to give a compound of the above formula (III)The yield of the compound was 95.7%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2-Aminophenyl)acetonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Gong Xiaoqian; Bu Gonggaofamingren; (9 pag.)CN105949109; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts