The chemical industry reduces the impact on the environment during synthesis 326-62-5, name is 2-(2-Fluorophenyl)acetonitrile, I believe this compound will play a more active role in future production and life. 326-62-5
To a soution of hydroxylamine hydrochloride (2.2 equiv.) and 2-(2-fluorophenyl)acetonitrile (1 equiv.) in methanol and water (5:1 ratio) was added sodium bicarbonate (2.4 equiv.). After stirring at 70 C for 20 h, the methanol was removed in vacuo and the resulting solution was diluted with water and dichloromethane (1:2 ratio). The layers were separated and the organic layer was washed with saturated aqueous sodium chloride. The organic layer was dried over magnesium sulfate, filtered, and the solvent was removed in vacuo to deliver the desired intermediate, 2-(2-fluorophenyl)-N-hydroxyacetimidamide (1 .13 g, 90% yield) as a white solid.
The chemical industry reduces the impact on the environment during synthesis 326-62-5. I believe this compound will play a more active role in future production and life.
Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; PERL, Nicholas; NAKAI, Takashi; LEE, Thomas Wai-Ho; RENNIE, Glen Robert; RENHOWE, Paul Allan; IYENGAR, Rajesh R.; (251 pag.)WO2016/44441; (2016); A1;,
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