4640-67-9, Name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, 4640-67-9, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
According to the method described in Embodiment 1,Add 1f (0.5 mmol, 82 mg), 2a (1.25 mmol, 173 mg) to a 15 mL pressure tube. Dichloro(pentamethylcyclopentadienyl)rhodium(III)dimer (0.025 mmol, 15 mg), copper acetate monohydrate (1 mmol, 200 mg), cesium acetate (0.25 mmol, 48 mg) and 1,2-Dichloroethane (2 mL) was sealed under an air atmosphere, and then placed in an oil bath at 80 C for 14 h. The reaction was quenched with 10mL of water was added, extracted with ethyl acetate (10mL ¡Á 3),The organic phase was washed successively with water and saturated brine and dried over anhydrous sodium sulfate. Filtration, rotary evaporation, over silica gel (petroleum ether/ethyl acetate = 5/1) to give a yellow solid column 3fa (141mg, 81%).
Statistics shows that 3-(4-Fluorophenyl)-3-oxopropanenitrile is playing an increasingly important role. we look forward to future research findings about 4640-67-9.
Reference:
Patent; Henan Normal University; Fan Xuesen; Guo Chenhao; Zhang Beibei; Zhang Xinying; Li Bin; (17 pag.)CN108997298; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts