60758-86-3, Adding some certain compound to certain chemical reactions, such as: 60758-86-3, name is 3-Ethoxy-4-methoxybenzonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 60758-86-3.
Dimethyl sulfone (53.1 g, 564 mmoles) was added to mixture of tetrahydrofuran (1000 ml) and dimethylsulfoxide (50 ml) and stirred at room temperature for 5-10 minutes. Sodium amide (22.02 g, 564 mmoles) was added slowly to the reaction mixture at 40C and stirred for 10-15 minutes. 3-ethoxy-4-methoxy benzonitrile (50 g, 282 mmoles) in tetrahydrofuran (200 ml) was added to the reaction mixture over a period of 30 minutes and was stirred for three hours at room temperature. The reaction mixture was distilled under reduced pressure at 40-45 C. Water (750m1) was added to the reaction mass and stirred at 35-40C for 30 minutes. The solid was filtered, washed with water (150 ml) and dried under reduced pressure at 45-50 C to give the title compound.Yield: 63.7 g (83%)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 60758-86-3.
Reference:
Patent; DR. REDDY?S LABORATORIES LIMITED; VAKAMUDI, Sree Naga Venkata Lakshmi Vara Prasad; KUNHIMON, Syam Kumar Unniaran; SARKAR, Soma Rani; IRENI, Babu; LEKKALA, Amarnath Reddy; RAPAKA, Gangadhara Chary; MADARAPU, Srinivasa Rao; NADGOUD, Ramesh Kumar; CHAGANTI, Sridhar; MUVVA, Venkateswarlu; FRYSZKOWSKA, Anna; FOX, Martin; SOLARES, Tamara Fanjul; SHANGAPU, Vijay Kumar; HASTAK, Nilesh; VYALA, Sunitha; RANGINENI, Srininvasulu; (49 pag.)WO2016/199031; (2016); A1;,
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