2032-34-0, A common compound: 2032-34-0, name is 3,3-Diethoxypropanenitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
Example 4 Methyl 2-[(2-cyanovinyl)amino]-4-ethoxy-5-acetylamidobenzoate (a compound of formula I, R=methyl) Trifluoroacetic acid (70 mL) was mixed with water (11 mL, 0.6 mol) at room temperature, and 2-cyanoacetaldehyde diethylacetal (23 mL, 0.15 mol, commercially available) was added thereto. The mixture was reacted for 12 h at room temperature to obtain a solution 1. In addition, the title compound of example 3 (a compound of formula II, i.e. methyl 4-ethoxy-5-acetylamido-2-aminobenzoate) (30 g, 0.12 mol) was suspended in ethyl acetate (400 mL), and the above obtained solution 1 was added thereto. The reaction mixture first turned to clear and then changed to cloudy. After reacted for 3-5 h at room temperature, the reaction was finished. The reaction mixture was filtered, washed with ethyl acetate and dried to give 35 g of the title compound as an offwhite powder with a yield of 96%. 1HNMR (300 MHz, DMSO) delta 1.39 (t, 3H), 2.06 (s, 3H), 3.82 (s, 3H), 4.25 (q, 2H), 5.14 (d, 1H), 7.05 (s, 1H), 8.21 (t, 1H), 8.41 (s, 1H), 9.02 (s, 1H), 10.41 (d, 1H). MS/ESI: 303.9 (M+H), 326.0 (M+Na), 302.0 (M-H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,3-Diethoxypropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Topharman Shangai Co., Ltd.; US2011/263860; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts