1735-53-1, Name is 4-Bromo-3-(trifluoromethyl)benzonitrile, 1735-53-1, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.
Dissolved aryl halide (1.0 equiv) in dry DMF and subjected to degassing with a gaseous mixture of (H2 + N2) balloon for three times. Added PdCl2(PPh3)2 (10 mol %) followed by Cul (8 mol%) at r.t. Added terminal alkyne (1.0 equiv. followed by TEA. The reaction mixture stirred at 50 C or 90 C. After cooling to room temperature, the resulting solution was subjected to rotary evaporation and partitioned between EtOAc and D.I. water. Aqueous layer was extracted with EtOAc 20 mL (3x). Combined organic layers were given water, brine washes and dried over anhydrous a2S04. After evaporation of the solvent, column chromatography on silica gel afforded the desired product.
Statistics shows that 4-Bromo-3-(trifluoromethyl)benzonitrile is playing an increasingly important role. we look forward to future research findings about 1735-53-1.
Reference:
Patent; LYNCH, Kevin; SANTOS, Webster; (353 pag.)WO2016/54261; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts