As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 198633-76-0 name is 2-Fluoro-6-methylbenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 198633-76-0
Commercially available 2-fluoro- 6-methylbenzonitrile (Apollo Scientific, 15.0 g, 1 1 1 mmol) was dissolved in triflic acid (75 mL) at 0 C then NBS (20.7 g, 1 17 mmol) was added. The reaction mixture was stirred at RT for 1 h then poured into ice water and extracted twice with DCM. The organic layer was washed with brine, dried over Na2S04, then filtered and evaporated to dryness to yield 3-bromo-6-fluoro-2- methylbenzonitrile: LC-MS: M+l= 216.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-6-methylbenzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PIO, Barbara; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; WALSH, Shawn; WO2013/90271; (2013); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts