105942-08-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 105942-08-3 as follows.
Step 1: To a three-necked flask equipped with a Dean-Stark separator was charged phenol (6.17 g, 65.63 mmol), potassium carbonate (17.28 g, 125 mmol), DMF (62.5 mL) and toluene (62.5 mL) under a nitrogen atmosphere. After refluxing for 4 hours, dehydration treatment was carried out until it was confirmed that no water was produced in the system. Thereafter, toluene (50 mL) was removed using a Dean-Stark separator. After returning to room temperature, 12.5 g of 4-bromo-2-fluorobenzonitrile (62.6 mmol) was added, and the mixture was refluxed under nitrogen for 4 hr. After completion of the reaction, 100 mL of toluene was added to the solution to dilute the solution, and the solution was filtered through celite, and the obtained filtrate was washed twice with a sep. funnel, dried over anhydrous magnesium sulfate, filtered, and evaporated under reduced pressure. The solvent is obtained to obtain a crude crystal product, which is purified by a column to obtain an intermediate.
According to the analysis of related databases, 105942-08-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Normal University; Dong Yongqiang; Xiang Xueqin; (13 pag.)CN108997299; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts