198633-76-0, name is 2-Fluoro-6-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 198633-76-0
To a cooled (0 OC) solution of 2-fluoro-6- methylbenzonitrile (5.0 g, 37 mmol) in 100 m of concentrated H2504 was added NBS (6.93 g,38.9 mmol). Then the mixture was stirred at O OC for 3 hrs and poured into ice-water (1 L). The solution was extracted three times with EtOAc (200 mL) and the combined orgianc layers werewashed with water and brine, dried oyer anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel fash chromatography to giye title compound.
Statistics shows that 198633-76-0 is playing an increasingly important role. we look forward to future research findings about 2-Fluoro-6-methylbenzonitrile.
Reference:
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DE JESUS, Reynalda, Keh; DING, Fa-xiang; DONG, Shuzhi; FRIE, Jessica; GU, Xin; JIANG, Jinlong; SHAHRIPOUR, Aurash; PIO, Barbara; TANG, Haifeng; WALSH, Shawn; WO2014/126944; (2014); A2;,
Nitrile – Wikipedia,
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