Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3556-60-3, name is 3-Methoxy-4-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., 3556-60-3
A mixture of 3-methoxy-4-methylbenzonitrile (3.5 g, 24 mmol), NBS (4.4 g, 25 mmol), and AIBN (0.39 g, 2.4 mmol) in benzene (240 mL) under nitrogen was heated at 85 C for 18 h, then cooled and concentrated. The residue was purified by silica gel chromatography (hexanes initially, grading to 50% EtOAc in hexanes) to give the title compound. MS: mlz = 226.0 [M+l]+.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; CROWLEY, Brendan; FRALEY, Mark; POTTEIGER, Craig; LIM, John; SHERER, Ed; YU, Younong; MITCHELL, Helen; BIFTU, Tesfaye; NAIR, Anilkumar; WANG, Cheng; YANG, De-Yi; ZHU, Cheng; KAR, Nam Fung; HUANG, Xianhai; CHEN, Lei; ZHOU, Wei; PARK, Min, K.; CAI, Jiaqiang; WO2015/161014; (2015); A1;,
Nitrile – Wikipedia,
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