94087-40-8,Some common heterocyclic compound, 94087-40-8, name is 3-Chloro-2-fluorobenzonitrile, molecular formula is C7H3ClFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 52: (3-chloro-2-(piperidin- -yl)phenyl)methanamine Step 1: To a solution of 3-chloro-2-fluorobenzonitrile (CAS 94087-40-8) (2.3 mmol) and piperidine (2.8 mmol) in 10 mL of DMF was added K2CO3 (4.6 mmol). The reaction was stirred at RT for 12 h, then the reaction mixture was extracted with water and EtOAc, washed with brine, dried over Na2S04, then concentrated in vacuo to provide 3-chloro-2-(piperidin-l- yl)benzonitrile as a yellow solid which was used in Step 2 without further purification.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloro-2-fluorobenzonitrile, its application will become more common.
Reference:
Patent; KAROS PHARMACEUTICALS, INC.; DE LOMBAERT, Stephane; GOLDBERG, Daniel R.; BRAMELD, Kenneth Albert; SJOGREN, Eric Brian; WO2015/89137; (2015); A1;,
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