133116-83-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 133116-83-3 name is 2-Fluoro-6-(trifluoromethyl)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 2-fluoro-6- (trifluoromethyl) benzonitrile (45 g, 0.238 mmol) in 60 mL of THF was added 1 M BH3: THF slowly at 60 oC and the resulting solution was refluxed overnight. The reaction mixture was cooled to ambient temperature. Methanol (420 ML) was added slowly and stirred well. The solvents were then evaporated and the residue was partitioned between EtOAc and water. The organic layer was dried over Na2SO4. Evaporation gave 4a as a yellow oil (46 g, 0. 238 mmol). MS (CI) m/z 194. 0 (MH+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Fluoro-6-(trifluoromethyl)benzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; WO2005/7633; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts