Adding some certain compound to certain chemical reactions, such as: 127946-77-4, name is 1-Amino-1-cyclopropanecarbonitrile hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127946-77-4. 127946-77-4
Into a 25-mL round-bottom flask, were placed (1R,2R)-2-(2-(5-chloropyridin-3-yl)-5-(4- (1,1 -dioxidothiomorpholino)phenyl)thiazol-4-yl)-4,4-difluorocyclohexanecarboxylic acid (10.0 mg, 0.018 mmol, 1.00 equiv), 1-aminocyclopropanecarbonitrile hydrochloride (12.0 mg, 0.101 mmol, 5.74 equiv), HATU (16.0 mg, 0.042 mmol, 2.39 equiv), DIPEA (26.0 mg, 0.20 1 mmol, 11.4 equiv) and DMF (1.5 mL). The resulting mixture was stirred for 16 h at ambienttemperature and diluted with ethyl acetate (5.0 mL). The resulting mixture was washed with brine (5.0 mL). The aqueous layer was extracted with ethyl acetate (3 x 10.0 mL). The combined organic layers were washed with brine (3 x 10.0 mL), dried (Na2504), filtered, and concentrated under reduced pressure. The residue was purified by preparative thin layer chromatography using ethyl acetate/petroleum ether (1:1). This resulted in 3.00mg (27%) of(1R,2R)-2-(2-(5-chloropyridin-3 -yl)-5 -(4-( 1,1 -dioxidothiomorpholino)phenyl)thiazol-4-yl)-N-( 1- cyanocyclopropyl)-4,4-difluorocyclohexanecarboxamide (Compound 2) as a light yellow solid:?H NMR (300 MHz, CDC13) Sppm 9.12 (s, 1H), 8.63 (s, 1H), 8.27 (s, 1H), 7.44 (d, J 9.0 Hz, 2H), 7.02 (d, J= 9.0 Hz, 2H), 5.92 (brs, 1H), 4.08-3.90 (m, 4H), 3.62-3.45 (m, 1H), 3.22-3.11 (m, 4H), 2.91-2.78 (m, 1H), 2.35-2.18 (m, 3H), 2.13-1.91 (m, 3H), 1.48-1.21 (m, 2H), 0.92-0.83(m, 2H); MS (ES, m/z): 632.1 (M + 1), 634.1 (M + 1).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-Amino-1-cyclopropanecarbonitrile hydrochloride.
Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn; PAONE, Daniel, V.; LI, Jing; GINNETTI, Anthony; LIM, John; FU, Jianmin; XU, Shimin; WO2015/54038; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts