194853-86-6, name is 4-Fluoro-2-(trifluoromethyl)benzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 194853-86-6
A mixture of 4-fluoro-2- (trifluoromethyl) benzonitrile (0.158 g, 0.84 mmol), 3,3, 3- TRIFLUOROPROPYLAMINE. HCI (0.125 g, 0.84 mmol) and DIEA (0.326 g, 2.52 MMOL) in DMSO (1.5 mL) was heated under nitrogen in a microwave at 200C for 20 min. The mixture was partitioned between Et2O and 0. 1 N HCI. The organic phase was washed with 0. 1 N HCI (twice) and brine, dried (NA2SO4), and concentrated in vacuo. The residue was purified by silica gel chromatography (0-50% EtOAc-hexane gradient) and the product crystallized from ET2O-HEXANES to give the title compound as a white solid (0.144 g, 61% yield): 1H NMR (400 MHz, CDCI3) 8 7.60 (d, J = 8.6 Hz, 1 H), 6.87 (d, J = 2.4 Hz, 1 H), 6.71 (dd, J = 8.6, 2.4 Hz, 1 H), 4.56 (bs, NH), 3.53 (q, J = 6.5 Hz, 2H), 2.51-2. 40 (m, 2H); MS (ES) M/Z 283 (M+1).
Statistics shows that 194853-86-6 is playing an increasingly important role. we look forward to future research findings about 4-Fluoro-2-(trifluoromethyl)benzonitrile.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/795; (2005); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts