A common heterocyclic compound, 1953-99-7, name is 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile, molecular formula is C8Cl4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 1953-99-7.
[formula c] 0.0375 mol, [formula a]0.0125 mol, zinc bromide 0.015 mol and1,8- diazabicyclo [5.4.0] undec -7-ene 0.05 mol were added to amylalcohol 66 g and stirred. The reaction temperature was raised to 130 and the reaction was carried out for 8 hours. After thereaction was complete, the reaction solution was cooled down and concentratedunder reduced pressure to remove the solvent by 2/3. The addition of methanolwas followed by to crystalize the solution. The crystals were filtered underreduce pressure and was dispersedly filtered in the mixed solution of methanol50g for 1 hour. The crystals were suction filtered and vacuum dried at 60 to obtain phthalocyanine compound 7.9g.
The synthetic route of 3,4,5,6-Tetrachlorobenzene-1,2-dicarbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kyung-In Synthetic Corporation; Park, Soon Hyeon; Kim, Jeong Ki; Kim, Jeong Rok; Lee, Yun Ah; Lee, Do kyeong; Lee, Min Jeong; Lee, Hui Jae; (16 pag.)KR2016/7024; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts