A common compound: 4640-67-9, name is 3-(4-Fluorophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 4640-67-9
In a 25 mL reaction tube with a Teflon magnetic stir bar,Add 0.5 mmol of 4-fluorobenzoylacetonitrile, 0.5 mmol of 3-bromo-1,1,1-trifluoroacetone, 0.5 mmol of sodium acetate,Finally, 58 mmol of 1,4-dioxane was added, and the reaction was stirred at room temperature for 8 hours.Add 15 mL of water, extract three times with 10 mL of ether, and combine the organic phases.Washing with saturated sodium chloride solution, drying over anhydrous magnesium sulfate, and then removing the organic solvent by rotary evaporation;The obtained crude product was eluted with n-pentane and ethyl acetate (10:1, v/v).2-(4-Fluorophenyl)-5-hydroxy-5-(trifluoromethyl)-4,5-dihydrofuran-3-carbonitrile was isolated by silica gel column chromatography (yield: 76%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4640-67-9, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Fuzhou University; Weng Zhiqiang; Wang Junwen; (29 pag.)CN110272400; (2019); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts