13388-75-5, Adding some certain compound to certain chemical reactions, such as: 13388-75-5, name is 2-(3,5-Dimethoxyphenyl)acetonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13388-75-5.
Under a nitrogen atmosphere, add 0.2 mmol of 3,5-dimethoxyphenylacetonitrile to a 25 mL reaction flask equipped with a reflux condenser.0.6 mmol of lithium tert-butoxide, 0.6 mmol of alpha-trifluoromethylstyrene, 4 ml of dimethyl sulfoxide, the reaction system was stirred at 80C for 12 hours,Stop heating and stirring, cool to room temperature, add water to quench the reaction, add ethyl acetate to extract the reaction solution,The ethyl acetate layer was subjected to rotary evaporation under reduced pressure to remove the solvent, and then separated and purified by column chromatography to obtain the target product,The column chromatography eluent used was a petroleum ether: ethyl acetate mixed solvent with a volume ratio of 30:1; the yield of the product was 83%.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13388-75-5.
Reference:
Patent; South China University of Technology; Zhu Chuanle; Cai Yingying; Zeng Hao; Jiang Huanfeng; (21 pag.)CN111205202; (2020); A;,
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