Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 327056-73-5, name is 3-Chloro-5-fluorobenzonitrile, A new synthetic method of this compound is introduced below., 327056-73-5
To a solution of 3-chloro-5-fluorobenzonitrile (E-1, 10 g, 64.28 mmol) and 6-chloro-2-fluoro-3-methyl-phenol (E-2, 9.38 g, 58.44 mmol) in DMA (100 mL) was added Cs2CO3 (1.9 g, 5.84 mmol) followed by K2CO3 (8.9 g, 64.28 mmol). The mixture was heated to 120 C. (oil bath) under argon for 5.5 h. The reaction was cooled to RT and water (150 mL) was added. The mixture was extracted with EtOAc (150 mL) and the aqueous phase back extracted with EtOAc (2¡Á100 mL). The combined EtOAc extracts were dried (MgSO4), filtered and concentrated in vacuo afford 11.1 g (75% purity) of E-3a as a white crystalline solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Roche Palo Alto LLC; US2009/12034; (2009); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts