As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2042-37-7 name is 2-Bromobenzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 2042-37-7
General procedure: The tetrazole compounds were prepared by a modified literature reported protocol.3 Thus, the aromatic nitrile (1.0 equiv), TBAF.3H2O (0.5 equiv) and TMS-N3 (1.5 equiv) were taken in a screw capped vial equipped with a magnetic stirrer and the resulting mixture was stirred vigorously at 85 oC. The reaction mixture was then transferred to a seperatory funnel and TBAF was removed by washing the organic phase with 1M aqueous HCl solution (20 ml). The organic phase was separated, washed with brine (20 ml) and dried over Na2SO4 and then concentrated in a rotary evaporator. The products were then purified by silica-gel (60-120 mesh) column chromatography or for some cases by recystallisation. Compound 2L was used as a crude mixture for further reaction. The compounds were then characterized by IR, NMR spectroscopy and mass spectrometry. Compounds 2A-B and 2H are reported compounds3 whereas 2C- 2G and 2I- 2L are new.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromobenzonitrile, and friends who are interested can also refer to it.
Reference:
Article; Bag, Subhendu Sekhar; Talukdar, Sangita; Anjali; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2044 – 2050;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts