In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1527-89-5, name is 3-Methoxybenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 1527-89-5
General procedure: In a pressurized sealed vial, aqueous hydroxylamine 50% w/w (4equiv) was added to a stirred solution of the appropriate carbonitrile(1 equiv) in absolute ethanol. The resulting mixture washeated at 90 C for 1 h. The solvent was then evaporated to drynessproviding the desired amidoxime quantitatively, which was usedwithout further purification.
The synthetic route of 1527-89-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Quadri, Marta; Silnovi?, Almin; Matera, Carlo; Horenstein, Nicole A.; Stokes, Clare; De Amici, Marco; Papke, Roger L.; Dallanoce, Clelia; European Journal of Medicinal Chemistry; vol. 160; (2018); p. 207 – 228;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts