A common compound: 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 610-66-2
General procedure: A mixture of aromaticaldehyde 1 (10 mmol), active methylene compound2 (10 mmol), and nano-ZnO catalyst (5 mol %) inaqueous ethanol (10 mL) was stirred under refl ux. Theformation of the products was monitored by TLC. Aftercompletion of the reaction (by TLC), the mixture wascooled to room temperature and fi ltered. The fi ltratewas concentrated to obtain a crude product, which waspurifi ed by recrystallization from aqueous ethanol.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 610-66-2, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Alam, M. M.; Asiri, Ya. I.; Sulthana, S. Sh.; Tasqeeruddin, S.; Russian Journal of Organic Chemistry; vol. 56; 2; (2020); p. 315 – 321;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts