In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 123-06-8 as follows. 123-06-8
In tert-butylhydrazine hydrochloride (8.67 g, 69.6 mmol)Was added triethylamine (9.7 mL, 69.6 mmol)After adding anhydrous ethanol (460 mL), the mixture was stirred and dissolved at room temperature,Ethoxymethylenemalononitrile (8.5 g, 69.6 mmol) was added in small portions.After heating the solution to reflux for 3 hours,After cooling, the solvent was evaporated to give an orange solid.And extracted with ethyl acetate (0.5 L) and water (0.25 L)After drying by adding magnesium sulfate,The organic layer was evaporated to give an orange-yellow solid.The resulting solid was continuously washed with a 10% ethyl acetate in cyclohexane solution to give a crystalline solid5-amino-1-tert-butyl hydrogen – pyrazol-4-cyano 9.54g(Yield: 83%).
According to the analysis of related databases, 123-06-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; West China Hospital, Sichuan University; He, Yang; Li, Weimin; Zhang, Li; (20 pag.)CN106008527; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts