6136-68-1, Adding a certain compound to certain chemical reactions, such as: 6136-68-1, name is 3-Acetylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6136-68-1.
Step l :OSodium hydride (60% dispersion in oil, 8.27 g, 207 mmol, 3.00 equiv) was added to a solution of 3-acetylbenzonitrile (10.0 g, 68.9 mmol, 1 equiv) in tetrahydrofuran (300 mL). The reaction mixture was stirred at 60 C, and a solution of diethyl carbonate (12.5 mL, 103 mmol, 1.50 equiv) in tetrahydrofuran (60 mL) was added over 45 minutes. The light orange reaction mixture was stirred at 60 C for an additional 2 h, then was cooled to 22 C. Saturated aqueous ammonium chloride solution was added, and the mixture was concentrated to -1/2 volume by rotary evaporation. The resulting residue was partitioned between ethyl acetate and water. The organic layer was washed with saturated aqueous sodium chloride solution, and the washed solution was dried over sodium sulfate. The dried solution was filtered, and the filtrate was concentrated to afford ethyl 3-(3-cyanophenyl)-3-oxopropanoate (15 g, 100%) as a white solid. The crude reaction product was taken into the next step without further purification. Calcd(M+l)+: 218.1, Found: 218.0.
According to the analysis of related databases, 6136-68-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BROWN, William, Colby; HEIDEBRECHT, Richard, W.; BRUBAKER, Jason; FISCHER, Christian; HENDRIX, John, T.; KELLEY, Elizabeth, H.; MACCOSS, Rachel, N.; METHOT, Joey, L.; MILLER, Thomas; OTTE, Karin, M.; SILIPHAIVANH, Phieng; REGER, Thomas; WILLIAMS, Peter, D.; WISCOUNT, Catherine, M.; WO2011/46774; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts