873-32-5, A common heterocyclic compound, 873-32-5, name is 2-Chlorobenzonitrile, molecular formula is C7H4ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: (0159) Pd precatalyst (0160) Base, solvent, (0161) temperature (0162) [0043] In a flask (e.g. 25 mL tube flask) equipped with a stir bar anda nitrogen pad was added an aryl halide (e.g. 1.0 mmol), an arylboronic acid (e.g. 1.1 mmol, 1.1 equiv.), octadecanol (internal standard, e.g. 0.50 mmol, 0. 50 equiv.), an organic solvent (e.g. 5 mL), water (e.g. 1 mL), and a base (e.g. 2.2 mmol, 2.20 equiv.). The mixture was purged with nitrogen (e.g. for 10 min), then a palladacycle precatalyst (e.g. 1 – 3 mol%) was added and the resulting mixture was stirred under nitrogen at the temperature indicated in the table below until the reaction was deemed complete by H NMR analysis. Aliquots (-0.05 mL) were immediately diluted with CDCb and analyzed by H NMR spectroscopy to determine the conversion and yield (yield was determined against the internal standard, (0163) octadecanol). Table 1 shows data for Suzuki couplings conducted according to the scheme above using the stated precatalysts. Entries 6, 8, and 9 are comparative. Tables 2 and 3 show data for Suzuki couplings conducted according to the scheme above using precatalyst 3.
The synthetic route of 873-32-5 has been constantly updated, and we look forward to future research findings.
Reference:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts