Adding some certain compound to certain chemical reactions, such as: 935-02-4, name is 3-Phenylpropiolonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 935-02-4. 935-02-4
General procedure: To a mixture of acetylene 2 (127 mg, 1 mmol) and S (32 mg, 1 mmol) was added 1-methylimidazole (1a; 82 mg, 1 mmol). The mixture was stirred at 20-25 C for 24 h. Column chromatography afforded thione 3a (132 mg, 67%), 4.3.8 (Z)-3-(3-Allyl-2-thioxo-2,3-dihydro-1H-imidazol-1-yl)-3-phenyl-2-propenenitrile (3f) Analogously, from acetylene 2 (127 mg, 1 mmol), S (32 mg, 1 mmol), and 1-allylimidazole (1f; 108 mg, 1 mmol) (20-25 C, 24 h) thione 3f (186 mg, 87%) was obtained as a yellow microcrystalline powder, mp 140-142 C (washed with ether). Initial imidazole 1f was recovered (23 mg, conversion was 79%). 1H NMR (400.13 MHz, CDCl3): delta=7.49-7.29 [m, 5H, Ho,m,p from C(6)-Ph], 6.90 (s, 1H, 4-H), 6.80 (s, 1H, 5-H), 6.07 (s, 1H, 7-H), 6.02-5.92 (m, 1H, Hx from N-Allyl), 5.34 (d, 3JHA,Hx=10.3 Hz, 1H, HA from N-Allyl), 5.28 (d, 3JHB,Hx=17.0 Hz, 1H, HB from N-Allyl), 4.70 (d, =5.9 Hz, 2H, N-CH2 from N-Allyl) ppm. 13C NMR (100.62 MHz, CDCl3): delta=164.3 (C-2), 154.3 (C-6), 132.6 [Ci from C(6)-Ph], 132.0 [Cp from C(6)-Ph], 131.3 (CHx from N-Allyl), 129.3 [Cm from C(6)-Ph], 126.9 [Co from C(6)-Ph], 119.7 (C-4), 118.4 (CHA,HB from N-Allyl), 117.2 (C-5), 114.7 (CN), 97.3 (C-7), 50.3 (CH2 from N-Allyl) ppm. IR (KBr): 2222 (CN), 1621 (C=C), 1398 (C=S) cm-1. Anal. Calcd for C15H13N3S (267.35): C, 67.39; H, 4.90; N, 15.72; S, 11.99. Found: C, 67.26; H, 4.81; N, 15.80; S, 11.69.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Phenylpropiolonitrile.
Reference:
Article; Belyaeva, Kseniya V.; Andriyankova, Ludmila V.; Nikitina, Lina P.; Mal’Kina, Anastasiya G.; Afonin, Andrei V.; Ushakov, Igor A.; Bagryanskaya, Irina Yu.; Trofimov, Boris A.; Tetrahedron; vol. 70; 5; (2014); p. 1091 – 1098;,
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