939-80-0, A common compound: 939-80-0, name is 4-Chloro-3-nitrobenzonitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
4-Chloro-3-nitro-benzonitrile (30 g, 165 mmol) was suspended in EtOH (60 mL), and methylamine (33% in EtOH, 24 ml, 165 mmol) was added. The mixture was stirred at room temperature for 1 h, then heated to 7O0C overnight. The reaction mixture was cooled to rt and concentrated in vacuo. The residue was suspended in Et2O and filtered to give 42 g of 4- methylamino-3-nitro-benzonitrile, which was used in the next step without further purification. 400 MHz 1H NMR (CD3OD) delta (ppm): 8.5 (s, 1 H), 7.70 (d, J = 9 Hz, 1H), 7.09 (d, J = 9 Hz, 1H), 3.29 (s, 3H); APCI” MS+ 177.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/12623; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts