1080-74-6, A common heterocyclic compound, 1080-74-6, name is 2-(3-Oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile, molecular formula is C12H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of intermediate 27 (370 mg, 0.24 mmol) in anhydrous chloroform (26 cm3) is added pyridine (1 .4 cm3, 17 mmol). The mixture is then degassed with nitrogen before 3-(dicyanomethylidene) indan-1 -one (280 mg, 1 .4 mmol) is added. The solution is then further degassed and stirred at 23 C for 20 minutes. The mixture is stirred at 40 C for 2 hours and then the solvent is removed in vacuo. The crude is triturated with ethanol (200 cm3) to produce a heavy suspension which is collected by filtration and the solid washed with acetone (50 cm3). The crude is dissolved in dichloromethane (20 cm3) added precipitated into acetone (250 cm3) to form a suspension. The solid collected by filtration to give compound 90 (437 mg, 96%) as a gray solid. 1H NMR (400 MHz, CDCIs) 8.87 (2H, s), 8.63 – 8.74 (2H, m), 8.13 (2H, s), 7.87 – 7.97 (2H, m), 7.68 – 7.82 (4H, m), 7.23 (8H, d, J 8.8), 6.90 (8H, d, J 9.0), 3.92 (8H, t, J 6.5), 1 .69 – 1 .84 (8H, m), 1 .16 – 1 .52 (72H, m), 0.80 – 0.97 (12H, m).
The synthetic route of 1080-74-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; MORSE, Graham; NANSON, Lana; MITCHELL, William; KROMPIEC, Michal; D’LAVARI, Mansoor; PRON, Agnieszka; (327 pag.)WO2018/65350; (2018); A1;,
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