A common heterocyclic compound, 6011-14-9, name is 2-Aminoacetonitrile hydrochloride, molecular formula is C2H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6011-14-9.
fluoroaniline 1.1 g, 0.01 mol dissolved in 30 ml 2M hydrochloric acid, add 40 ml of water diluted, then sodium nitrite 0.7 g, 0.01 mol dissolved in a small amount of water, 0 C under the reaction of diazonium salt solution, To this temperature was added dropwise a solution of 1.0 g of aminoacetoacetonitrile hydrochloride, 0.01 ml of a 30 ml aqueous solution, and the reaction was stirred for 2 hours;A-2, add excess sodium acetate 25-30 grams dissolved after standing overnight, petroleum ether extraction crude, and then recrystallized in petroleum ether 1-p-fluoro-azidophenyl-3-nitrile-triazene (A) 1.9 grams, the melting point of 95-96 C, the yield of 95%;
The synthetic route of 2-Aminoacetonitrile hydrochloride has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hebei Maison Chemical Co.,ltd; Yue, gang; Guan, Deng shi; Yang, Shi yan; (17 pag.)CN104130243; (2016); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts