151-18-8, A common compound: 151-18-8, name is 3-Aminopropanenitrile, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.
At room temperature,To a solution of 4- (2- (1-methyl-1H-pyrazol-4-yl) -5 – ((2- (trimethylsilyl) ethoxy) methyl) -5H-pyrrolo [ 3-b] pyrazin-7-yl) cyclohexanone (15 mg, 0.03 mmol)3-aminopropionitrile (30 [mu] L, 0.41 mmol)Of tetrahydrofuran (4 mL)Was added sodium triacetoxyborohydride (12 mg, 0.05 mmol)Stirred at room temperature for 6 hours,(20 mL), extracted with dichloromethane (20 mL x 3), dried over anhydrous sodium sulfate and concentrated column chromatography (dichloromethane / methanol (v / v) = 10/1) to give 12 mg of a yellow oil, yield: 70.98%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Aminopropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Huang Jiuzhong; Zheng Changchun; Zhang Yingjun; Ouyang Luo; Mao Hongfen; Nie Biao; Xu Juan; Chen Hongfen; (137 pag.)CN106336413; (2017); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts