610-66-2, Adding a certain compound to certain chemical reactions, such as: 610-66-2, name is 2-(2-Nitrophenyl)acetonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 610-66-2.
To a solution of 2- nitrophenylacetonitrile (162 mg, 1 mmol) in anhydrous DMSO (5 mL) was added K2C03 (152 mg, 1.1 mmol) and the reaction mixture was stirred for 10 min under nitrogen atmosphere. Butyl iodide (125 //L, 1.1 mmol) was added to the reaction mixture and the stirring was continued for 3 h. Water was added to the reaction mixture and it was extracted with EtOAc (3 x 20 mL). The combined organic layer was dried over Na2S04, concentrated under reduced pressure, and the crude material was purified by silica gel column chromatography (10%> EtOAc/hexanes) to afford compound A2 as a pale yellow oil (174 mg, 80%>). Rf = 0.50 (10%> EtOAc/hexanes).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Nitrophenyl)acetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE UNIVERSITY OF KANSAS; DAVID, Sunil, Abraham; YOO, Euna; SHUKLA, Nikunj; SALYER, Alex, Christopher; BEESU, Mallesh; MALLADI, Subbalakshmi, S.; JONES, Cassandra; WO2015/23958; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts