218632-01-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 218632-01-0 as follows.
4-Cyano-2-fluoro-1 -nitrobenzene (300 mg, 0.0018 mol, 1 eq), 1-(tetrahydro-2H-pyran-4- yl)-4~piperidinamine (D9, 330 mg, 0.0018 mol, 1 eq), diisopropylethylamine (350 mg, 0.0027 mol, 1.5 eq), and dimethylformamide (5ml) were combined, heated to 2000C and held for 1 min in a microwave reactor. 100 ml of water was then added and the reaction extracted with 2 x 75 ml dichloromethane. The dichloromethane layers were combined, dried with sodium sulfate, and evaporated to yield the title compound which was used without further purification in the next step. MS (ESI): 331 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 218632-01-0, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2007/36711; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts