40497-11-8, Adding some certain compound to certain chemical reactions, such as: 40497-11-8, name is Ethyl 2,3-dicyanopropanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 40497-11-8.
Sodium nitrite (224 mg, 3.25 mmol) was added carefully to sulphuric acid (concentrated, 1 ml), ensuring that the temperature did not rise above 30 C. After stirring at 15 C. for 1 h, acetic acid (2 ml) was added, followed by Preparation 36 (850 mg, 3.24 mmol) in acetic acid (3 ml). The reaction mixture was then heated at 50 C. for 1 h and cooled to room temperature. To a solution of Preparation 24 (500 mg, 3.29 mmol) in acetic acid (5 ml) was added ice water (5 ml), followed by the solution of the diazonium salt, added dropwise at 0 C. After complete addition, ammonium hydroxide (6 ml) was added and the reaction mixture was stirred overnight at room temperature. The reaction mixture was filtered through Arbocel and the filtrate was concentrated in vacuo. The residue was partitioned between dichloromethane and water and the organic phase was separated, dried (Na2SO4) and concentrated in vacuo to give Preparation 70 (1.0 g). MS (ES): M/Z [MH+] 353.0; expected mass for C11H5Cl2F3N4S+H is 353.0 1H-NMR (CDCl3): 6.01-6.03 (1H), 7.75-7.78 (2H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 40497-11-8.
Reference:
Patent; Billen, Denis; Chubb, Nathan Anthony Logan; Gethin, David Morris; Hall, Kim Thomas; Roberts, Lee Richard; Walshe, Nigel Derek Arthur; US2005/148649; (2005); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts