The chemical industry reduces the impact on the environment during synthesis 2-Cyano-N,N-diethylacetamide. I believe this compound will play a more active role in future production and life.
26391-06-0, The chemical industry reduces the impact on the environment during synthesis 26391-06-0, name is 2-Cyano-N,N-diethylacetamide, I believe this compound will play a more active role in future production and life.
EXAMPLE-.Preparation of N,N-DIETHYL-2-CYANO-3-(3-lambdalambdaETHOXY-4-HYDROXY-S-NITROPHENYL)ACRYL AMIDE. ; STEP-I; 3-Methoxy-4-hydroxy-5-nitrobenzaldehyde of the formula (6) 150.0 gm (0.761 mole), N,N-diethyl cyanoacetamide of the formula (4) 135.3 gm (0.96 mole), glycine 10.5 gm (0.13 mole) and acetic acid 25.12 gm (0.41 mole) were charged sequentially to 1500.0 ml toluene. The resulting reaction mixture was heated to reflux and maintained with removal of water by azeotropically for 12-15 hrs. After the completion of reaction the solvent is concentrated and quenched into a cooled solution of isopropy. alcohol, aqueous HBr and water (2400.0 ml) and stirred for 3 hrs. The precipitated solid is filtered and dried to get 229.0 gm (94.2%) of title product of trhe formula (7) as crystalline solid. This product is used for next stage with out purification.
The chemical industry reduces the impact on the environment during synthesis 2-Cyano-N,N-diethylacetamide. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SUVEN LIFE SCIENCES LTD.,; WO2007/94007; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts