These common heterocyclic compound, 935-02-4, name is 3-Phenylpropiolonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 935-02-4
General procedure: A solution of benzimidazole 1a-c (1.0 mmol) in dry acetonitrile (0.3 ml) was added to a solution of phenylcyanoacetylene (2) (127 mg, 1.0 mmol) and isothiocyanate 3a-c (1.0 mmol) in dry acetonitrile (0.2 ml). The reaction mixture was stirred at 50-55C for 12-20 h. The solvent was removed, and carbothioamides 4a-e were separated by chromatography on an alumina column using 20:4:1 chloroform-benzene-ethanol as the eluent.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 935-02-4.
Reference:
Article; Andriyankova; Nikitina; Belyaeva; Mal’Kina; Afonin; Vashchenko; Smirnov; Trofimov; Chemistry of Heterocyclic Compounds; vol. 50; 6; (2014); p. 807 – 813; Khim. Geterotsikl. Soedin.; vol. 50; 6; (2014); p. 876 – 882,7;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts