Simple exploration of 3939-09-1

Statistics shows that 3939-09-1 is playing an increasingly important role. we look forward to future research findings about 2,4-Difluorobenzonitrile.

3939-09-1, name is 2,4-Difluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 3939-09-1

Example 3 1-(2,4-Diamino-quinazolin-7-yl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-indol-4-one (Compound 3); 2,4-Difluorobenzonitrile (2.78 g, 1 eq), guanidine hydrochloride (7.15 g, 3.74 eq), and sodium hydride (3.6 g, 7.6 eq) are added to dimethylacetamide (50 mL) and the resulting mixture is stirred at 150 C. for overnight. Then the reaction mixture is poured into sat’d NaHCO3 aq. solution (300 mL), extracted by EtOAc (3¡Á200 mL). The combined organic layers is dried over Na2SO4, filtered, concentrated. The crude product is purified by flash chromatography to give 7-Fluoro-quinazolin-2,4-diamine (1 g, 28% yield). LC/MS m/z=179 [M+H]+.

Statistics shows that 3939-09-1 is playing an increasingly important role. we look forward to future research findings about 2,4-Difluorobenzonitrile.

Reference:
Patent; Huang, Kenneth He; Veal, James; Barta, Thomas; Smith, Emilie D.; Ma, Wei; Ommen, Andy; US2008/70935; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts