79463-77-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 79463-77-7 as follows.
A solution of 5-amino-2-[(pyrrolidin-1-yl)methyl]benzoxazole (200 mg, 0.92 mmol) and diphenylcyanocarbonimidate (263 mg, 1.10 mmol) in isopropyl alcohol (3.5 mL) was stirred overnight at ambient temperature, the resulting white solid product, (Z)-phenyl /V- cyano-/V-(2-(pyrrolidin-1-ylmethyl)benzo[d]oxazol-5-yl)carbamimidate, was filtered and used directly for the next step (290 mg, 87%).
According to the analysis of related databases, Diphenyl N-cyanocarbonimidate, the application of this compound in the production field has become more and more popular.
Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; WO2008/83354; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts