Some common heterocyclic compound, 19472-74-3, name is 2-Bromophenylacetonitrile, molecular formula is C8H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 19472-74-3
The appropriate amount of organic solvent (volume ratio of 1: 1,4-dioxane and a mixture of DMSO (dimethyl sulfoxide). 2), the compound on 100mmol formula (I), 200mmol formula (II) compound, 8mmol bicomponent catalyst (as 4mmol (a-taPhos)2PdCl2And 4 mmolCu (TFA)2The mixture), 5mmol phosphine ligand L1 and methanesulfonic acid 20mmol acidic compound; and then stirred warmed to 60 , and the reaction was stirred at this temperature for 12 hours.After completion of the reaction, filtered hot and the filtrate was cooled to room temperature, and the pH was adjusted to neutral, and then washed with deionized water sufficiently shaken, and then ethyl acetate was added and extracted 3 times, the combined organic phase was concentrated under reduced pressure, the concentrate was subjected to silica gel column chromatography, a volume ratio of 1: 2 acetone – chloroform mixture to wash, to afford the compound of formula (III), in a yield of 97.3%.
The chemical industry reduces the impact on the environment during synthesis 2-Bromophenylacetonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Zhang, Yan; (9 pag.)CN105384674; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts