56043-01-7, The chemical industry reduces the impact on the environment during synthesis 56043-01-7, name is 2-Amino-6-methylbenzonitrile, I believe this compound will play a more active role in future production and life.
A solution of 2-amino-6-methylbenzonitrile (1.32 g, 10 mmol) and sulfamide (4.81 g, 50 mmol) in dry 1,4-dioxane (50 mL) was refluxed under nitrogen for 3 days. After the reaction mixture was cooled down to room temperature, the precipitate was filtered and washed with dioxane. The filtrate was concentrated under reduced pressure, and the residue was purified by chromatography on silica gel eluding with EtOAc/hexanes (3:7) to give the title compound as a pale-white solid. 1H NMR (400 MHz, DMSO-d6) delta 2.44 (s, 3H), 7.19-7.21 (m, 3H), 7.39-7.41 (d, J=8.4 Hz, 1H), 7.53 (t, J=8.0 Hz, 1H), 9.41 (s, 1H).
The chemical industry reduces the impact on the environment during synthesis 2-Amino-6-methylbenzonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SENOMYX, INC.; US2008/306053; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts