A common compound: 4640-66-8, name is 4-Chlorophenacylcyanide, belongs to nitriles-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 4640-66-8
Synthesized from the crude title compound of PREPARATION 87 and chloroacetic anhydride following the method of PREPARATION 76. The title compound was first partially purified by normal-phase chromatography and then purified by reverse-phasechromatography using the Isolera Purification system. Yield: 50% over two steps. Purity 100%.1H NMR (400 MHz, Chloroform-d) ppm 7.24 – 7.18 (m, 2H), 6.88 – 6.76 (m, 2H),4.67 (s, 2H), 4.34 (t, J = 6.5 Hz, 2H), 3.24 (t, J = 6.5 Hz, 2H).UPLC/MS (3 mm) retention time 1 .82 mm.LRMS: m/z 273 (M+1, 2xCl).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4640-66-8, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ALMIRALL, S.A.; AIGUADE BOSCH, Jose; CONNOLLY, Stephen; EASTWOOD, Paul Robert; GOMEZ CASTILLO, Elena; MORENO MOLLO, Immaculada Montserrat; ROBERTS, Richard Spurring; SEVILLA GOMEZ, Sara; (216 pag.)WO2017/60488; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts