10406-25-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10406-25-4, name is 4-(Aminomethyl)benzonitrile, A new synthetic method of this compound is introduced below.
Biphenyl-3 -carboxylic acid (500mg, 2. 52mmol) and 4-aminomethyl-benzonitrile (425mg, 2.S2mmol) were suspended in DCM (25mL) and DIPEA (873uL, 5.O4mmol), EDC (484mg, 2.S2mmol) and HOBt (3 86mg, 2.S2mmol) were added. The reactionmixture was stirred overnight, concentrated in vacuo and partitioned between EtOAc (lOOmL) and water (lOOmL). The organic fraction was washed with water (lOOmL), sat aq NaHCO3 (5OmL), brine (5OmL), dried (MgSO4) and concentrated in vacuo to give the title compound (738mg, 94%) as a brown solid. LCMS: ES 313.0 [IVIHf.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher; WO2014/20351; (2014); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts