42872-74-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42872-74-2, name is 3-Bromo-4-methylbenzonitrile, This compound has unique chemical properties. The synthetic route is as follows.
[0152] To a solution of 2 (300 mg, 137 mmol) in toluene (15 mL) was added 3- bromo-4-methylbenzonitrile (402 mg, 2.05 mmol), racemic-2,2′-bis(diphenylphosphino)-l,l’- binaphthyl (170 mg, 0.27 mmoi) and cesium carbonate (892 mg, 2.74 mmol). The mixture was purged with nitrogen for 10 min. Tris(dibenzylideneacetone)dipaliadium(O) (125 mg, 0.14 mmoi) was added and the mixture was heated to 110 C for 16 h, then diluted with ethyl acetate (20 mL) and filtered through celite. The solution was concentrated in vacuo, the residue was purified by chromatography (silica gei, 0-15% ethyl acetate/methylene chloride) to afford Example 61 as a light yellow solid (111 mg, 24%): 1H NMR (300 MHz, DMSO-d6) delta 7.76 (d, J = 2.1 Hz, 1H), 7.74-7.73 (m, 3H), 7.27 (s, 1H), 7.06 (d, J = 2.1 Hz, 1H), 3.96 (s, 3H), 2.37 (s, 3H), 2.28 (s, 3H), 2.18 (s, 3H); ESI m/z 335 [M + H)
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Patent; ZENITH EPIGENETICS CORP.; JIANG, May, Xiaowu; MOLINO, Bruce, Francis; LIU, Shuang; WANG, Ruifang; DUFFY, Bryan, Cordell; QUINN, John, Frederick; WAGNER, Gregory, Steven; (114 pag.)WO2016/87942; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts