50712-68-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50712-68-0, name is 4-Chloro-2-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 1 2-methyl-4-(2′,4′-dichlorophenoxy)benzonitrile A stirred solution of 4-chloro-2-methylbenzonitrile (7.8 g., 0.05 mole) and the potassium salt of 2,4-dichlorophenol (10.07 g., 0.05 mole) in 50 ml. of dimethyl acetamide was heated for 30 hours at 150 C. The cooled reaction mixture was diluted with 200 ml. of water to precipitate a brown oil. From this oil, an ether extract yielded 12.0 g. of an oil. A vacuum distillation of the oil gave 8.6 g. of 2-methyl-4-(2′,4′-dichlorophenoxy)benzonitrile with a boiling point of 163-166 C. at 0.05 mm Hg. and a melting point of 52-55 C.
The synthetic route of 4-Chloro-2-methylbenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mobil Oil Corporation; US4029493; (1977); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts