Sources of common compounds: 179898-34-1

Statistics shows that 179898-34-1 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-fluorobenzonitrile.

179898-34-1, name is 3-Bromo-5-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 179898-34-1

A solution of 3-bromo-5-fluorobenzonitrile (2.5g, 12.5mmol), (trimethylsilyl)acetylene(2.86ml,20mmol), bis(acetate)bis(triphenylphoshpino)Palladium(II) (936mg, 1.25mmol) and triethylamine (35ml) in toluene (35ml) was degassed by bubbling nitrogen through the solution and then stirred at 950C for 30 minutes. Filtration and concentration to yield a crude product. It was diluted with EtOAc (150ml). The organic phase was washed with saturated NaHCO3 solution (50ml), brine (50ml) and the organic layer was dried over sodium sulfate. Filtration EPO and concentration to yield a product A293.1 (2Ag, 88%). HPLC: 95%, retention time: 4.05 minute (condition A). LC/MS (M+H)+ = 218.2.

Statistics shows that 179898-34-1 is playing an increasingly important role. we look forward to future research findings about 3-Bromo-5-fluorobenzonitrile.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/122137; (2006); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts